Oncolytic Virus Immunotherapy exemplifies an exciting cancer treatment which stimulates a patient-specific immune response against cancer by making use of a virus’ ability to replicate and kill tumor tissue selectively. Immune- stimulating chemicals are produced by genetically modifying the Oncolytic Viruses which also makes them more specific for cancer cells. Therapeutic cancer vaccines and mAb therapy are some of the cancer immunotherapies with which Oncolytic virus immunotherapy are often combined.